Thioredoxin-interacting Protein (Txnip) Gene Expression
نویسندگان
چکیده
منابع مشابه
Thioredoxin Interacting Protein (TXNIP) and Pathogenesis of Diabetic Retinopathy.
Chronic hyperglycemia (HG)-associated reactive oxygen/nitrogen species (ROS/RNS) stress and low grade inflammation are considered to play critical roles in the development of diabetic retinopathy (DR). Excess glucose metabolic flux through the aldose reductase/polyol pathway, advanced glycation end product (AGE) formation, elevated hexosamine biosynthesis pathway (HBP), diacyl glycerol/PKC acti...
متن کاملHypoxia Induced High Expression of Thioredoxin Interacting Protein (TXNIP) in NSCLC and its Prognostic Effect
Thioredoxin interacting protein (TXNIP), also known as vitamin D3 upregulated protein (VDUP-1) or thioredoxin binding protein-2 (TBP-2), was originally reported as a gene of unknown function in HL-60 cells induced by 1α, 25-dihydroxyvitamin D3 (Chen and DeLuca, 1994). The human TXNIP gene is located on chromosome 1q21.1, contains 8 exons and is 4174 bp in length. The human TXNIP protein consist...
متن کاملNitrosative/Oxidative Stress Conditions Regulate Thioredoxin-Interacting Protein (TXNIP) Expression and Thioredoxin-1 (TRX-1) Nuclear Localization
Thioredoxin (TRX-1) is a multifunctional protein that controls the redox status of other proteins. TRX-1 can be found in the extracellular milieu, cytoplasm and nucleus, and it has distinct functions in each environment. Previously, we studied the intracellular localization of TRX-1 and its relationship with the activation of the p21Ras-ERK1/2 MAP Kinases signaling pathway. In situations where ...
متن کاملThioredoxin-Interacting Protein (TXNIP) Suppresses Expression of Glutamine Synthetase by Inducing Oxidative Stress in Retinal Muller Glia Under Diabetic Conditions
BACKGROUND Diabetic retinopathy (DR) is a progressive neurodegenerative disease with early-stage symptoms such as dysfunction of Muller cells, which leads to ganglion cell death. Its pathogenesis is probably associated with oxidative stress and a recently discovered protein, thioredoxin-interacting protein (TXNIP). MATERIAL AND METHODS To explore the role of TXNIP in DR, we cultured Muller cell...
متن کاملA role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis
Creatine is important for energy metabolism, yet excitable cells such as cardiomyocytes do not synthesize creatine and rely on uptake via a specific membrane creatine transporter (CrT; SLC6A8). This process is tightly controlled with downregulation of CrT upon continued exposure to high creatine via mechanisms that are poorly understood. Our aim was to identify candidate endogenous CrT inhibito...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m110.108290